Dispersing particles in a solution is a key requirement for a great variety of industrial products and processes, including pigments in coating applications or fillers in polymers. To be highly functional in the finished product, nanoparticles are required to be finely and homogeneously dispersed. As nanoparticles are often highly aggregated due to van der Waals interactions and sintering bonds, high stresses must be exerted on the constituent particles. High pressure dispersion is a promising new technology for deagglomerating and reducing process time and energy. Taking account of the influence of different mechanisms causing aggregate disruption, homogenizing pressure and nozzle geometry are the key process parameters. Therefore, adapting the nozzle geometry can lead to a targeted improvement of dispersion efficiency.