A thermodynamic model for pressure-induced quasi-isochoric superheating of nanoparticles embedded in rigid matrixes was established quantitatively by introducing the size dependence of melting enthalpy. The accuracy of the developed model was verified with the reported experimental data of Sn and Pb nanoparticles encapsulated in fullerene-like graphitic shells (FGS) as well as Ge nanoparticles embedded in SiO2. The mechanism behind the smaller superheating for Al nanoparticles embedded in Al2O3 was also studied. It was found that the extent of the superheating is determined by the pressure, which is in turn related to the confinement effect and to the size of the nanoparticles. Through the knowledge obtained in this study, it can be concluded that the extreme superheating of nanoparticles can be achieved on the proviso that they are encased in a sufficiently rigid matrix, while the size of nanoparticles is small enough.