키틴유도체의 Amphiphilic Supramolecule 응집구조에 관한 연구

한애란; Fuhrhop JH

Polymer(Korea), Vol.18, No.5, 671-676, September, 1994

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키틴유도체의 Amphiphilic Supramolecule 응집구조에 관한 연구

Amphiphile Uberstrukturen aus Chitin-Derivaten

한애란, Fuhrhop JH

초록

1N NaOH와 1N HCl로 대하의 천연 키틴을 정제하여 순수한 키틴을 제조하였다. 47%의 NaOH용액으로 키틴을 탈아세틸화 시켜 순수한 키토산을 얻었다. 여기에 화합물 5를 반응시켜 소수성의 긴사슬을 가지는 유도체를 얻었으며 그것의 응집구조를 전자현미경을 이용하며 관찰하였다. 그 결과는 여러개의 판상층이 평형으로 모여진 결정구조였으며 그 구조의 모델을 제시하였다.

Pure Chitin was obtained from lobster shell by simple treatments with 1N NaOH and 1N HCl solutions. It was converted into Chitosan by deacetylation with an aqueous 47% NaOH. By selective stearoylation with an amphiphile 5 a Chitosan having hydrophobic side chains was prepared and its supramolecular structure investigated by sanning electron microscopic means. It was found that this Chitin derivative arrregates into a 1amellar crystal structure.

Keywords:amphiphilic;supramolecule;chitin

[References]

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[1] Muzzarelli RAA, Natural Chelating Polymers, "Alginic Acid, Chitin and Chitosan," p. 83, Pergamon Press, Oxford, New York, Toronto, Sydney, Braunschweig (1973)

[2] Foster AB, Webber JM, Adv. Carbohyd. Chem., 15, 371 (1960)

[3] Gow NA, Gooday G, Carbohydr. Res., 165, 105 (1987)

[4] Austin PR, Brine CJ, Science, 212, 749 (1981)

[5] Schreiber W, Nach. Chem. Tech. Lab., 25, 305 (1977)

[6] Kennedy JF, "Carbohydrate Chemistry," p. 632, Clarendon Press Inc., Oxford (1988)

[7] Maruea R, Suder BJ, Wighman JP, J. Appl. Polym. Sci., 27, 4827 (1982)

[8] Fuhrhop JH, Boettcher C, J. Am. Chem. Soc., 112, 1768 (1990)

[9] Frieser M, Frieser L, J. Am. Chem. Soc., 78, 2825 (1956)

[10] Kurita M, Sannan T, Iwakura Y, Makromol. Chem., 178, 2595 (1977)

[11] Mima S, Miya M, Iwamoto R, Yoshikawa S, J. Appl. Polym. Sci., 28, 1909 (1983)

[12] Hesse, Meier, und Zeeh "Spektroskopische Methoden in der Organischen Chemie," p. 94, Thiemen Verlag (1984)

[13] Revol JF, Gardner KH, Chanzy H, Biopolymers, 27, 345 (1988)