Numerical simulations including detailed chemical and physical models are performed to investigate the influence of different physical parameters on the auto-ignition of n-heptane/iso-octane droplets in air. Simulations are performed for isobaric conditions with an ambient pressure of 8 bar and a droplet radius of 200 mu m. The ambient gas temperature ranges from 800 K to 2000 K and the droplet temperature was varied from 300 K to 400 K. Below an ambient temperature of 1000 K the ignition delay time is found to increase with an increasing volume fraction of iso-octane. Above 1000 K the ignition delay timed appears to be almost independent of the mixture composition of the droplet. The local ignition conditions are also studied. It turns out that ignition occurs at points, where the mixture is lean. This trend is more significant, if the ambient temperature increases. The influence of physical properties of the mixture components, like diffusion coefficients, heat conductivity, heat of vaporization and vapor pressure, is investigated. Furthermore, the influences of simplifying assumptions such as the distillation and diffusion limit are studied. (C) 2007 Elsevier Ltd. All rights reserved.