Two chiral supramolecules with enantiomeric three-dimensional porous host frameworks, (Delta) {[Fe-II(phen)(3)][(FeNa)-Na-III(C2O4)(3)]}(n) (1) and (Lambda) {[Fe-II(phen)(3)][(FeNa)-Na-III(C2O4)(3)]}(n) (2) (phen)1,10-phenanthroline), have been synthesized, and their crystal structures have been determined. The structural analysis shows that compounds 1 and 2 are a pair of enantiomers, both consisting of a three-dimensional porous skeleton formed by (Delta)/(Lambda){[(FeNa)-Na-III(C2O4)(3)](2-)}(n) and guest (Delta)/(Lambda)[Fe(phen)(3)](2+) units. The circular dichroism spectrum measurements confirmed the optical activity and the enantiomeric nature of complexes 1 and 2.