A study was carried out to investigate the effect of heat-pipe air-handling coil on energy consumption in a central air-conditioning system with return air. Taking an office building as an example, the study shows that compared with conventional central air-conditioning system with return air, the heat-pipe air-conditioning system can save cooling and reheating energy. In the usual range of 22-26 degrees C indoor design temperature and 50% relative humidity, the RES (rate of energy saving) in this office building investigated is 23.5-25.7% for cooling load and 38.1-40.9% for total energy consumption. The RES of the heat-pipe air-conditioning system increases with the increase of indoor design temperature and the decrease of indoor relative humidity. The influence of indoor relative humidity on RES is much greater than the influence of the indoor design temperature. The study indicates that a central air-conditioning system can significantly reduce its energy consumption and improve both the indoor thermal comfort and air quality when a heat-pipe air-handling coil is employed in the air-conditionmg process. (c) 2006 Elsevier B.V. All rights reserved.