Preparation and Characterization of Bis-ethylhexyloxyphenolmethoxyphenyltriazine (BEMT) Loaded Solid Lipid Nano-particles (SLN)

Geun-Soo Lee; Dong-Hwan Lee; Ki-choon Kang; Chun-Il Lee; Hyeong-Bae Pyo; Tae-Boo Choi

Journal of Industrial and Engineering Chemistry, Vol.13, No.7, 1180-1187, December, 2007

Geun-Soo Lee^{1, 2}, Dong-Hwan Lee², Ki-choon Kang², Chun-Il Lee², Hyeong-Bae Pyo², and Tae-Boo Choi^{1, †}

¹Department of Bioengineering, Konkuk University, Seoul, 143-701, Korea
²Hanbul Cosmetics Co., R & D Center, Chungbuk, 369-834, Korea

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Bis-ethylhexyloxyphenolmethoxyphenyltriazine (BEMT) is one of the most widely used chemical UVA+UVB double absorbers in sunscreen products. The purpose of this study is to establish the characterization of solid lipid nano-particles containing BEMT (BEMT-SLNs) within a sunscreen agent. For this experimental study, the external micrographs of the SLNs show that they are usually spherical, nonporous and uniform with a smooth surface. The particle’s diameter varied between about 330 to 500 nm and the encapsulation efficiencies ranged from 77.8 to 89.2 %. The diameter of BEMT particle encapsulated by solid lipid capsules with 50 wt% polyol content decreased to 330 nm compared to 20 wt%, but the loading capacity did not change. It can be ascertained that BEMT.SLNs shows a small third peak indicating the βi form and a lower crystallinity index (C.I.) value. The residual BEMT content gradually decreased to 80.9 % over 12 h as a result of UV radiation, but the residual BEMT content with an encapsulated solid lipid decreased only to 92.3 %. The SLN improve photochemical stability of BEMT in the sunscreen products.

Keywords:SLN;bis-ethylhexyloxyphenolmethoxyphenyltriazine;cetyl palmitate;chemical UV absorber;crystallinity

[References]

Magdassi S, Bach U, Mumcuoglu KY, J. Microencapsul., 14(2), 189 (1997)
Kang KC, Lee CI, Pyo HB, Jeong NH, J. Ind. Eng. Chem., 11(6), 847 (2005)
Wissing SA, Muller RH, Int. J. Pharm., 254, 65 (2003)
Jenning V, Thunemann AF, Gohla SH, Int. J. Pharm., 199, 167 (2000)
Muller RH, Mader K, Gohla SH, Eur. J. Pharm. Biopharm., 50, 161 (2000)
Muller RH, adtke M, Wissing SA, Adv. Drug Deliv. Rev., suppl., 1, 131, 54 (2002)
Jang SJ, Choi SS, Kim YO, Park JH, Comprehension of Cosmetics, 1st Edn, p. 54, Pungnam, Korea (2006)
Ritte L, Fisher GJ, Aging Reserch reviews, 1, 705 (2002)
Anderson MW, Hewitt JP, Spruce SR, Sunscreens, Nadim A. Shaath Ed., Sunscreens, pp. 263-283, Marcel Dekker, New York (1997)
Yener G, Incegul T, Yener N, Int. J. Pharm., 258, 203 (2003)
Sylvia A, Wissing RH, Muller, Int. J. Pharm., 242, 377 (2002)
Sylvia A, Wissing RH, Muller, Int. J. Pharm., 254, 65 (2003)
Hou D, Xie C, Zhu C, Biomaterials, 24, 1781 (2003)
Lee EJ, Yoon MS, Rang MJ, J. Soc. Cosmet. Scientists Korea, 30, 53 (2004)
Feritas C, Muller RH, Eur. J. Pharm. Biopharm., 47, 125 (1999)
Ruckmani K, Sivakumar M, Ganeshkumar PA, J. Nanosci. Nanotechnol., 6, 2991 (2006)
Tiyaboonchai W, Plianbangchang P, Int. J. Pharm., doi:10.1016/j.jpharm. 2006. 12. 043 (2007)
Muller RH, Ruge SA, Solid lipid nanoparticles (SLN) for controlled drug delivery., p. 219, Harwood Academic publishers, Amsterdem (1998)
Western K, Bunjes H, Koch. MHJ, J. Control. Release, 48, 223 (1997)
Lagevelde A, Hollander F, Schenk H, Acta Crystallogr. Sect. B-Struct. Sci., B55, 114 (1999)
Souto EB, Mehnert W, Muller RH, J. Microencapsul., 23, 417 (2006)
Jenning V, Gohla S, Int. J. Pharm., 196, 219 (2000)
Jenning V, Gohla S, J. Control. Release, 66, 115 (2000)
Souto EB, Muller RH, Gohla S, J. Microencapsul., September, 22, 581 (2005)
Menhert W, Mader K, Adv. Drug Deliv. Rev., 47, 165 (2001)

[Referenced By]

[1] Magdassi S, Bach U, Mumcuoglu KY, J. Microencapsul., 14(2), 189 (1997)

[2] Kang KC, Lee CI, Pyo HB, Jeong NH, J. Ind. Eng. Chem., 11(6), 847 (2005)

[3] Wissing SA, Muller RH, Int. J. Pharm., 254, 65 (2003)

[4] Jenning V, Thunemann AF, Gohla SH, Int. J. Pharm., 199, 167 (2000)

[5] Muller RH, Mader K, Gohla SH, Eur. J. Pharm. Biopharm., 50, 161 (2000)

[6] Muller RH, adtke M, Wissing SA, Adv. Drug Deliv. Rev., suppl., 1, 131, 54 (2002)

[7] Jang SJ, Choi SS, Kim YO, Park JH, Comprehension of Cosmetics, 1st Edn, p. 54, Pungnam, Korea (2006)

[8] Ritte L, Fisher GJ, Aging Reserch reviews, 1, 705 (2002)

[9] Anderson MW, Hewitt JP, Spruce SR, Sunscreens, Nadim A. Shaath Ed., Sunscreens, pp. 263-283, Marcel Dekker, New York (1997)

[10] Yener G, Incegul T, Yener N, Int. J. Pharm., 258, 203 (2003)

[11] Sylvia A, Wissing RH, Muller, Int. J. Pharm., 242, 377 (2002)

[12] Sylvia A, Wissing RH, Muller, Int. J. Pharm., 254, 65 (2003)

[13] Hou D, Xie C, Zhu C, Biomaterials, 24, 1781 (2003)

[14] Lee EJ, Yoon MS, Rang MJ, J. Soc. Cosmet. Scientists Korea, 30, 53 (2004)

[15] Feritas C, Muller RH, Eur. J. Pharm. Biopharm., 47, 125 (1999)

[16] Ruckmani K, Sivakumar M, Ganeshkumar PA, J. Nanosci. Nanotechnol., 6, 2991 (2006)

[17] Tiyaboonchai W, Plianbangchang P, Int. J. Pharm., doi:10.1016/j.jpharm. 2006. 12. 043 (2007)

[18] Muller RH, Ruge SA, Solid lipid nanoparticles (SLN) for controlled drug delivery., p. 219, Harwood Academic publishers, Amsterdem (1998)

[19] Western K, Bunjes H, Koch. MHJ, J. Control. Release, 48, 223 (1997)

[20] Lagevelde A, Hollander F, Schenk H, Acta Crystallogr. Sect. B-Struct. Sci., B55, 114 (1999)

[21] Souto EB, Mehnert W, Muller RH, J. Microencapsul., 23, 417 (2006)

[22] Jenning V, Gohla S, Int. J. Pharm., 196, 219 (2000)

[23] Jenning V, Gohla S, J. Control. Release, 66, 115 (2000)

[24] Souto EB, Muller RH, Gohla S, J. Microencapsul., September, 22, 581 (2005)

[25] Menhert W, Mader K, Adv. Drug Deliv. Rev., 47, 165 (2001)