Biochemical and Biophysical Research Communications, Vol.291, No.5, 1297-1301, 2002
Solution structure of intracellular signal-transducing peptide derived from human beta(2)-adrenergic receptor
The structure of intracellular third loop peptide (betaIII-2: RRSSKFCLKEKKALK) was studied by CD and NMR spectroscopy. According to the CD study, this peptide forms a helix in the TFE solution. The three-dimensional molecular structure in TFE was determined by the 2D H-1 NMR spectroscopy. The structure consists of a positive charge cluster on the C-terminal side of the peptide chain. This part will be an active site of the peptide interacting with the G-protein. (C) 2002 Elsevier Science (USA).