Water-insoluble copolymer was synthesized by grafting N-vinyl pyrrolidone on gelatin-PVA complex for the possibility of artificial skin-substitute. The water content of copolymer ranged 77∼88% and increased with gelatin contents. The tensile strength of synthesized film was 240 kg /cm² in dry state and 2∼4 kg/cm² in wet state. Elongation was 5% in dry state and increased to 220∼350% when the material soaked the water. The oxygen permeability of 2.2∼4.5×10^-7cm³(STP)cm/cm²·sec·cmHg was considered to be reasonably good. Water vapor transmission rate showed 0.4g/cm²/day, greater than that for a desired artificial skin. The rate of biodegradation was fast initially and reached to an equilibrium state after 2∼8days, and increased with gelatin contents. The shape of membrane was sustained even after 40∼70% of degradation. The modified gelatin- PVA having antimicrobial(silver sulfadiazine) was prepared to evaluate the effect of the suppression of bacterial proliferation. The release rate of first 12 hours was 70∼80%, meaning that this material was showed the effective suppression of bacterial proliferation. The residual antimicrobial was believed to prevent the infection of bacteria during wound healing. The present material seems to be suitable for wound dressing.