An approach for the high throughout preparation and characterization of aqueous pigment dispersions is described and evaluated. The use of ultrasonication as a rapid technique for dispersing pigments using polymeric dispersants was developed. The results are comparable to those obtained using time-intensive conventional high-energy ball mall processing. The quality of the pigment dispersion was evaluated in a high-throughput fashion using digital image analysis and the results correlated with particle sizes, determined by photo-correlation spectroscopy.