Macromolecular Rapid Communications, Vol.16, No.10, 749-755, 1995
SYNTHESIS OF NOVEL GLYCOPEPTIDE-POLYOXAZOLINE BLOCK-COPOLYMERS BY DIRECT COUPLING BETWEEN LIVING ANIONIC AND CATIONIC POLYMERIZATION SYSTEMS
A never glycopeptide-containing block copolymer, poly[O-(tetra-O-acetyl-beta 3-D-glucapyranosyl)-L-serine]-block-poly(2-methyl-2-oxazoline) (5), was synthesized by mutual termination of living polymerizations of a sugar-substituted a-amino acid N-carboxyanhydride (NCA) (1) and 2-methyl-2-oxazoline (3). 5 was deacetylated to provide the glycopeptide-polyoxazoline block copolymer, poly[O-(beta-D-glucopyranosyl)-L-serine]-block-poly(2-methyl-2-oxazoline) (6).