Advanced Materials, Vol.18, No.8, 991-991, 2006
Biomolecular recognition of crystal defects: A diffuse-selection approach
Phage display has been used to find an amino acid sequence that shows binding affinity for surface defects in germanium. A general approach called "diffuse selection" is employed to find consensus peptide sequences (see figure) demonstrating binding specificity for highly defective crystal surfaces versus non-defective crystal surfaces. This approach may be useful for selecting semiconductors with specific doping profiles from diffuse targets with large competing backgrounds.