Polypyrrole (PPy) may be set to revolutionize biological applications such as tissue engineering and biosensors due to its high electroactivity/conductivity and the water compatibility of its films. However, inherent weaknesses in PPy-based materials arise from defect sites along the PPy polymer backbone, and its instability to reduction by biologically relevant reducing agents such as dithiothreitol (DTT) and glutathione. Here is presented a family of electron-rich poly(3,4-alkylenedioxypyrrole)s that address these structural weaknesses and are stable in the conducting, oxidized form, rendering them immune to strong biological reducing agents.