Solvent design, the selection of an optimal solvent in MSA driven technologies and reaction path synthesis, the selection of an optimal route in a network of alternative reactions for the manufacture of a desired product, constitute two key steps in arriving at environmentally sound designs. In this work, the Methodology for Environmental Impact Minimization introduced recently by the authors is extended to include aspects of solvent selection and reaction path synthesis. Trade-offs are explored regarding cost and environmental impact objectives. A case study, involving the production of acetaldehyde, is presented to illustrate the potential of the methodology.