This paper presents a systematic and integrated approach to the design of energy efficient crude distillation systems. Integrated implies simultaneous consideration of the options in the distillation system and the heat exchanger network. The proposed procedure is applicable for grass-roots as well as revamp situations. The approach is based on a combination of insights in distillation and Pinch Analysis. First, the complex refinery towers are decomposed into a sequence of simple columns. Then, the procedure explores the trade-off between steam stripping and reboiling and the impact of thermal coupling and pump arounds. The tower design changes are considered in simulation mode while the preheat train modifications are evaluated simultaneously based on Pinch Analysis targets. This combination allows quick identification of promising configurations at an early stage in the design. Using the proposed approach for new designs it is possible to identify radically different designs than typically used in the industry today.