According to the operation characteristics of such plants, on the basis of Mauderli-Wellons’s research, the mathematical models of operation optimization are modified which consider the campaign formation and production plan problem respectively. A new heuristics is advanced to search for the dominant production campaigns. Comparing the heuristics with Mauderli’s algorithm, it ensures that parallel items in-phase have the same batch and that each production line operates with optimized batch, therefore the plant has a larger processing rate. This heuristics can effectively relieve the bottlenecks, and avoid the complexity resulting from the nonconvexity of the model. Within the resource alocated, the mixed-integer algorithm is used to maximize the profit.