While both the dynamic modelling, and to a lesser extent, the optimisation of reactive batch distillation have been studied in the past, issues related to the control and on-line operation of such a process have not been properly addressed. In this study a,priori optimal profiles of the operating variables are established for an industrial reactive distillation by maximising the profitability of the process subject to constraints on the reboiler temperature and the accumulator composition. The control properties at optimal and non-optimal conditions are assessed. A PI-controller is designed to implement the optimal profiles and the controller performance is tested using a simulation model including disturbances in the reaction model and reboiler heat duty. The fully automatic operation of the process, according to the optimal policies, is demonstrated in conjunction with a real time control system.