To reduce toxicity of organic solvents and to improve low temperature stability of adhesives, two new mixed solvent systems were identified. Based on solubility of Neoprene, two solvent systems selected were acetone/cyclohexane and acetone/S-100. New solvent system reduced toxicity to less than half of the existing adhesive without any sacrifice of adhesion strengths. However, the phenolic resin which was added to improved adhesion was best at 25% level to Neoprene for the maximum adhesion strengths. The low temperature stability which has been a problem of the small-package adhesive was good with the acetone/cyclohexane mixed solvent system containing 30∼43% of acetone.