Chemistry Letters, Vol.36, No.5, 636-637, 2007
A new access to 3-halo-3,3-difluoropropanoic acid derivatives via fluorine-halogen exchange reaction of silyl enolates of 3,3,3-trifluoropropanoic acid derivatives
On the treatment of silyl enolates derived from N-(3,3,3-trifluoropropanoyl)oxazolidinones with 2.0 equiv. of titanium(IV) halide at -20 degrees C for 2 h, a novel fluorine-halogen exchange reaction occurred efficiently to give 3-halo-3,3-difluoropropanoic imides in high yields.