Chemistry Letters, Vol.35, No.11, 1304-1305, 2006
Highly efficient synthesis and imaging studies of an arylpiperazine derivative as a 5-HT1A receptor imaging agent
A novel and straightforward microwave synthesis of a new arylpiperazine 3 which has an N2S2 moiety has been developed and radiolabeled with an optimum radionuclide of technetium in the presence of a borohydride exchange resin (BER) as a reducing agent. According to the present study this new radiolabeled compound 4 could have the potential for a diagnostic application as an imaging agent of a serotonin neuro-receptor.