The amorphous Ti-Si mixed oxides prepared from chloride precursors using a one-step nonhydrolytic sol-gel route could serve as efficient gold catalyst supports for gas-phase epoxidation of propylene in O-2 and H-2. A propylene conversion of 6.8% at the initial 60 min and 4.0% after 4 h of time-on-steam, keeping a selectivity to propylene oxide as high as 95%, was obtained over the gold supported on a Ti-Si mixed oxide containing 10 mol % of Ti.