The calculation of single and binary breakthrough curves of CH4 and CO on activated carbon were performed with a complex model for the nonisothermal multicomponent adsorption in nonadiabatic fixed beds on the basis of an uniform parameter set for different measuring conditions. The VS-model was applied to describe the isotherms of the pure gases and the gas mixtures. The shape of the single breakthrough curves was less influenced by mass transport resistances but strong determined by the radial heat transport in the adsorbens bed. A good conformity was found when the diffusion coefficients were kept at a constant value. However, different values were used for calculating breakthrough curves varying the entrance concentration. An empirical relation between entrance concentration and the model diffusion coefficients was estimated. The binary breakthrough curves were calculated satisfactorily considering the variation of the volume flux during the adsorption process.