Nanobiomaterials have become of broader interest over the past few years. In this review, we demonstrate functional biomolecules that we have constructed based on the biophysical data on nucleotides. We propose three concepts for the development of new nanobiomaterials; DNB (Databasing or Designable Nanobio) is the process of storing the biomolecular properties, ENB (Engineering Nanobio) is the process of conversion of the biomolecular properties to a molecular design, and FNB (Functional Nanobio) is the process of constructing functional molecules based on DNA technologies. Our approach of DNB -> ENB -> FNB can be the central dogma for a molecular design.