Chemistry Letters, Vol.33, No.9, 1212-1213, 2004
The first enantiomerically pure synthesis of (S)- and (R)-Naftopidil utilizing Hydrolytic Kinetic Resolution of (+/-)-(alpha-naphthyl) glycidyl ether
Hydrolytic Kinetic Resolution (HKR) of (+/-)-(alpha-Naphthyl) glycidyl ether with (R,R)-salen Co(III) OAc complex provided enatiomerically pure (S)-naphthyl glycidyl ether and (R)-1-naphthyl glycerol; opening of the corresponding pure terminal epoxide with 1-(2-methoxyphenyl)piperizine gave the enantiomerically pure (S)- and (R)-Naftopidil.