Chemistry Letters, Vol.33, No.9, 1168-1169, 2004
A novel L-proline catalyzed Biginelli reaction: One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones under solvent-free conditions
A Novel efficient and simple synthetic protocol for the Biginelli reaction has been developed for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones in a one-pot three-component condensation of aldehydes, beta-dicarbonyl compounds, and urea or thiourea by using 10 mol % L-proline as the catalyst under solvent free condition.