Chemistry Letters, Vol.33, No.3, 240-241, 2004
Cytoplasmic molecular delivery by hematoporphyrin derivative-based photodynamic treatment using high-intensity pulsed laser irradiation
Photosensitized HeLa cells receiving high-intensity pulsed laser irradiation exhibited pores on the membrane surface. We attempted to deliver FITC-labeled dextran (71.6kDa) into the cell cytoplasm. The ratio of FITC-positive cells in photodynamic-treated HeLa cells was significantly higher than that of non-treated HeLa cells, with no loss in cell viability.