Chemistry Letters, Vol.31, No.5, 522-523, 2002
Halogenolactamization of 2-(3-butenyl)-1,3-oxazolines to bifunctional gamma- and delta-lactams
Under new conditions described herein. halogenolactamization of 2-(3-butenyl)-1,3-oxazolines (1) proves to be a successful approach for producing 1,5-bis(halogenoalkyl)-gamma-lactams (3). A variety of halogens can be introduced by using reagents such as I-2, I-2/CuCl2, I-2/CuBr2, and Br-2 under dry conditions.