Chemistry Letters, Vol.29, No.9, 1066-1067, 2000
Thermodynamic consequences of single-mutation on association of an antibody with its specific antigen: The case of HyHEL-10-hen lysozyme complex
The interactions between protein antigen and its specific antibodies with one-point mutation have been investigated using isothermal titration calorimetry. Some mutation led to the increase in enthalpy change, and others to the decrease. Contributions of each amino acid to the interaction could be classified with two types, i.e., enthalpic and entropic.