Chemistry Letters, Vol.29, No.1, 80-81, 2000
Synthetic studies toward potent cytotoxic agents amphidinolides: Synthesis of the C-1-C-6 and C-9-C-17 moieties of amphidinolides O and P
Stereoselective synthesis of the (4R)-C-1-C-6 and (14R, 15R)-C-9-C-17 segments, 4 and 5 respectively, of amphidinolides O and P have been achieved starting from a common chiral precursor 6 which was obtained by radical-mediated opening of a trisubstituted epoxy alcohol using Cp2TiCl-cyclohexa-1,4-diene.