Molecular dynamics simulations have been employed to investigate the volatilization of the enkephalin embedded in it rapidly heated H2O film. Simulations are performed for three different energy inputs, 103%, 89% and 69% to vaporize the entire film. The cluster formed for each system undergoes a fast decomposition. The decomposition leads to a rapid temperature drop and proceeds differently for the different energy inputs. For 103% energy input, the explosive evaporation is the dominant process while, For 69%, energy input, the normal evaporation plays a significant role in the cluster decomposition. (c) 2005 Elsevier B.V.. All rights reserved.