A theoretical analysis of a compression/ejection hybrid cycle for domestic refrigeration is presented in this paper. In this cycle, an ejector is employed to reduce the loss of available energy due to the large temperature difference between the fresh food section and the freezer section. A theoretical model is established and simulated with FORTRAN. Thermodynamic properties of working fluids are obtained with the package REFPROP, version 8.0. The performance of this system using several refrigerants (R123, R124, R141b, R290, R152a, R717, R600a, and R134a) is presented. The results show that the entrainment ratio and the coefficient of performance depend mainly on the fluid nature and the operating conditions. According to the results of simulation of the hybrid cycle using several refrigerants, the ejection cycle can reach a higher coefficient of performance compared with the standard cycle. R141b gives the most excellent performances.