In this paper, reactive stripping in monolithic reactors is studied experimentally and theoretically. For the experiments, different monolith types are coated with a catalyst and operated in cocurrent and countercurrent mode. The esterification of 1-octanol and hexanoic acid is investigated in a batch-recycle mode; the liquid phase is recirculated, whereas the stripping gas nitrogen with the stripped water is vented after each pass through the column. The experimental results show that the conversion of equilibrium-limited esterifications can be increased using reactive stripping, the process performance being influenced by the monolith type and operating mode. The theoretical description is given by a rate-based model, which is successfully validated against the experimental data and used to conduct sensitivity studies, with regard to operating parameters and different reactive zone arrangements within the monoliths.