The blends of polyamide (PA) and ultra high molecular weight polyethylene (UHMWPE) were prepared by a Brabender DSE25 co-twin screw extruder, and maleic anhydride (MAH) grafted high-density polyethylene (HDPE) was used as a compatibilizer. A chemical reaction between MAH group of MAH-g-HDPE and terminal amino group of PA was testified by FT-IR analysis. Mechanical and tribological tests showed that the tensile and bending strength of PA decrease with the increase of UHMWPE. Besides, the mechanical strengths of PA/UHMWPE blends were improved by adding appropriate MAH-g-HDPE. The chemical reaction between MAH-g-HDPE and PA ameliorated the homogeneous dispersing ability of UHMWPE in the blend. The friction coefficient and volume wear rate of the PA/UHMWPE blends decreased apparently with the increase of UHMWPE, as was probably that UHMWPE has straight chain structure and good flexibility; therefore, a transferring film could be easily formed on the steel surface with the increase of UHMWPE. In friction process, the wear resistance of the blends was relative to the mechanical property of the blends when the amount of the transferring layer reached to a certain value.