Polydimethylsiloxanes (PDMS) have been extensively utilized for their ability to spread and lubricate surfaces. This ability can be mostly attributed to their low surface energy and extremely flexible backbone. This study examines their unique ability through a comparative analysis of the rates of spread of numerous commercially available oils and lubricants, including a series of methyl-terminated PDMS. The analysis facilitated the design and synthesis of two homologous series of PDMS, in which the terminal ends were functionalized as quaternary ammonium salts. The two new series of compounds were examined for their ability to spread both as neat liquids and as formulated blends. Additionally, these hybrid ionic oligomers were screened for biological activity against Staphylococcus aureus. All of the new oligomers exhibited antimicrobial properties in preliminary testing. (c) 2007 Wiley Periodicals, Inc.