화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.15, No.3, 195-201, April, 2007
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Chitosan and Its Derivatives for Gene Delivery
Kuen Yong Lee†
  • Department of Bioengineering, Hanyang University, Seoul 133-791, Korea
E-mail:
Non-viral vectors, including lipid- or polymer-based systems, have attracted much attention to date as a gene delivery vehicle, due to safety issues with viral vectors. Chitosan, a naturally existing cationic polymer, has shown great potential as a gene delivery carrier, as it has low immunogenicity and toxicity, excellent transcellular transport ability, and is relatively easy to chemically modify. This review summarizes and discusses the general features of chitosan and its applications as a delivery carrier of DNA and RNA.
Keywords:chitosan;nanoparticle;gene delivery;targeting;siRNA
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