A model is proposed to investigate the deactivation through coke formation by accounting for active surface coverage and pore blockage under nonisothermal conditions in a two-dimensional pore network. The system is governed by the Thiele modulus, the Prater number, and the activation energies of the reactions involved. Two simple reactive paths are considered for the simulations, showing that the activity's prediction can differ strongly from the isothermal case both over time and with its coke content.