The oxidation chemistry of hypoxanthine nucleosides and nucleotides viz., mosine, 2'-deoxyinosine, inosine-5'-monophosphate and inosine5'-triphosphate has been studied in the pH range 2.1-11.1 at pyrolytic graphite electrode. In all the four compounds oxidation occurs in 6H(+), 6e process at physiological pH (7.2) leading to the formation of allantoin as a major product. The products dimers; and tetramers formed in the secondary electrode reactions depend on the nature of sugar molecule (ribose or deoxyribose) present and number of phosphate moieties attached to the sugar moiety. A comparison of redox chemistry and formation of electrooxidised products of inosine and its derivatives has been presented in this paper. (c) 2006 Elsevier Ltd. All rights reserved.