Spray-drying technology is used in a wide variety of processes ranging from manufacture of food products to pharmaceuticals. Most recently, spray-drying technology has also been explored to make hollow microparticles. This work presents an approach that designs a spray-drying chamber using a rate-based description combined with a droplet size distribution model. The major criterion in the design is the desired moisture content of the final particle. The predictions of the final particle properties are compared to experimental data obtained from a laboratory spray-drying unit. The results show that the final spray-drying design is sensitive to liquid feed flow rate, inlet drying gas temperature, and heat loss.