In this paper, a film-model-based description of multicomponent reactive separation is considered and two different approaches to the solution of the reaction-mass transfer problem in the liquid film are studied and compared. The first approach is based on a numerical treatment of the resulting nonlinear boundary value problem. The second approach requires a simplification of the differential transport equation by linearizing its reaction source term, and further, takes advantage of an analytical technique. To realize numerical solution of a complex matrix-form boundary value problem, a special method has been developed and tested. Both approaches have strengths and weaknesses which are analyzed and discussed. For different systems and process conditions, a comparison of simulation results obtained by both methods is carried out.