Maxwell-Stefan theory was applied for simulating a multicomponent, macropore molecular-diffusion-controlled fixed-bed adsorption process. Simulations were also made based on the conventional Fick formulation. By comparing the simulation results with experimentally measured column dynamics for the adsorption of O-2-N-2-He mixture on 5A zeolite, it was found that both sets of simulations agree with each other and are in good agreement with the experimentally observed behaviour.