A nuclear heating reactor (NHR) was designed with the required inherent safety and simplified design features. Power capacity of the NHR-200 (200 MW(th), with steam production of 380 t/h) is compatible with reasonably sized desalination plants. Thermal-hydraulic parameters of the produced steam (2.4 bar and 124 degrees C) are suitable for coupling with distillation processes. Economic competitiveness of the NER desalination plant is the key point to which the public and decision-makers are paying good deal of attention. Coupling of the NHR with selected MED processes and design parameters of an integrated desalination plant are described. Results of analyses of water production costs are presented as well. Based on the economic evaluation, the average energy cost of the nuclear plant may reach 5.44 $/t of steam, and the provided water production cost may reach 0.72 $/m(3) and 0.76 $/m(3) for coupling with HT-VTE-MED and LT-HTE-MED processes, respectively.