Crystallization of acetaminophen micro-particle using supercritical carbon dioxide

Guanghua Li; Junho Chu; Eun-Seok Song; Kyung Ho Row; Kyong-Hwan Lee; Youn-Woo Lee

Korean Journal of Chemical Engineering, Vol.23, No.3, 482-487, May, 2006

DOI10.1007/BF02706753 Export Citation

Crystallization of acetaminophen micro-particle using supercritical carbon dioxide

Guanghua Li, Junho Chu¹, Eun-Seok Song¹, Kyung Ho Row , Kyong-Hwan Lee², and Youn-Woo Lee^{1, †}

Center for Advanced Bioseparation Technology, Department of Chemical Engineering, Inha University, 253 Yonghyun-dong, Nam-gu, Incheon 402-751, Korea
¹School of Chemical & Biological Engineering and Institute of Chemical Process, Seoul National University, San 56-1, Sillim-dong, Gwanak-gu, Seoul 151-744, Korea
²Energy Conversion Research Department, Korea Institute of Energy Research, Daejeon 305-343, Korea

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Fine particles of acetaminophen were produced by Aerosol Solvent Extraction System (ASES). The experiments were conducted to investigate the effects of various temperatures, pressures, solvents, solution concentrations and solution feed volume rates on particle size and morphology. The choice of solvent appears to be very important for getting specific particle shape and size. The result shows that when ethyl acetate is used as a solvent, the irregular and acicular morphology of raw material is recrystallized to be regular and monoclinic. The average particle size of recrystallized acetaminophen from ethyl acetate solution has been measured to be 3-4 μm, which was about 1/20th of raw acetaminophen in size. The particle size distribution range also became narrow from 82 μm to 4.9 μm.

Keywords:Acetaminophen;Supercritical Fluid;Anti-solvent;Particle

[References]

Chattopadhyay P, Gupta RB, Ind. Eng. Chem. Res., 40(16), 3530 (2001)
Gilbert DJ, Palakodaty S, Slaan R, York P, “Particle engineering for pharmaceutical application - a process scale up,” The 5th International Symposium on Supercritical Fluids, April, Atlanta (2000)
Hanna M, York P, “Method and apparatus for the formation of particles,” WO 95/01221, International Publication Date 12, 01 (1995)
Jung J, Perrut M, J. Supercrit. Fluids, 20, 179 (2001)
Lee JH, Kim S, Korean Chem. Eng. Res., 42(2), 202 (2004)
Lee YW, HWAHAK KONGHAK, 41(6), 679 (2003)
Matson DW, Peterson RC, Smith RD, J. Mater. Sci., 22, 1919 (1987)
Perez-Ruiz T, Martinez-Lozano C, J. Pharm. Biomed. Anal., 38, 87 (2005)
Reverchon E, Adami R, J. Supercrit. Fluids, 37, 1 (2006)
Reverchon E, J. Supercrit. Fluids, 15(1), 1 (1999)
Wubbolts FE, Bruinsma OSL, Rosmalen GM, J. Cryst. Growth, 198, 767 (1999)

[Referenced By]

[Related Articles]

[1] Chattopadhyay P, Gupta RB, Ind. Eng. Chem. Res., 40(16), 3530 (2001)

[2] Gilbert DJ, Palakodaty S, Slaan R, York P, “Particle engineering for pharmaceutical application - a process scale up,” The 5th International Symposium on Supercritical Fluids, April, Atlanta (2000)

[3] Hanna M, York P, “Method and apparatus for the formation of particles,” WO 95/01221, International Publication Date 12, 01 (1995)

[4] Jung J, Perrut M, J. Supercrit. Fluids, 20, 179 (2001)

[5] Lee JH, Kim S, Korean Chem. Eng. Res., 42(2), 202 (2004)

[6] Lee YW, HWAHAK KONGHAK, 41(6), 679 (2003)

[7] Matson DW, Peterson RC, Smith RD, J. Mater. Sci., 22, 1919 (1987)

[8] Perez-Ruiz T, Martinez-Lozano C, J. Pharm. Biomed. Anal., 38, 87 (2005)

[9] Reverchon E, Adami R, J. Supercrit. Fluids, 37, 1 (2006)

[10] Reverchon E, J. Supercrit. Fluids, 15(1), 1 (1999)

[11] Wubbolts FE, Bruinsma OSL, Rosmalen GM, J. Cryst. Growth, 198, 767 (1999)