We present a comprehensive approach to the simultaneous design and control of a continuous stirred tank reactor (CSTR) for styrene solution polymerization that must be able to produce different polymer grades. The resulting tool allows simultaneous selection of the polymerization equipment, the multivariable feedforward-feedback controller's structure and tuning parameters, the steady states and the transition paths between them. For this purpose a multiobjective optimization is implemented to minimize the annualized reactor cost, the operating costs, the production of off-specification polymer and the transition time between steady states. Trade-offs between the sometimes conflicting objectives are dealt with by the optimization. Unlike many previous grade transition studies, steady states are not known a priori. The only known parameters are the target molecular weights to be produced at each steady state. We have analyzed three different scenarios, and propose practical criteria for selecting the most reasonable optimum when the solution is not unique. (c) 2006 Elsevier Ltd. All rights reserved.