The design of a novel micro-screw pump for viscous fluid is described. The device consists of a rotating screw in the centre of the channel, connected with a shaft and micro motor. The objective of this research is to investigate the effect of using various screw geometries on the pump performance. Theoretical analysis by finite volume simulations is carried out to study the influence of pitch, diameter of the screw and the thread (flight depth) to evaluate the optimal dimensions for the pump and to obtain the maximum flow rate. When the screw rotates, a net force is transferred to the fluid due to the differential pressure on the depth of the thread and pressure gradient along the screw axis, thus causing the fluid to displace. The three-dimensional simulations indicate a gradual increase of the average velocity with increasing the screw diameter. The maximum average velocity can be obtained when the ratio between the pitch and screw diameter (pi/d) is 0.6. Effective pumping is achieved by increasing the thread and pitch at maximum screw diameter. The numerical simulation has been validated experimentally.