The catalytic oxidation of toluene over -Al2O3 supported copper-manganese oxide catalysts in the temper-ature range of 160-280℃ was investigated by employing a fixed bed flow reactor. The catalysts were characterized byBET, scanning electron microscopy (SEM), temperature-programmed reduction(TPR), temperature-programmed oxida-tion(TPO), X-ray photoelectron spectroscopy (XPS) and X-ray diffraction(XRD) techniques. Catalytic oxidation of tol-uene was achieved at the below 280℃, and the optimal content of copper and manganese in the catalyst was found to be15.0 wt％Cu-10.0 wt％Mn. From the TPR/TPO and XPS results, the redox peak of 15Cu-10Mn catalyst shifted to thelower temperature, and the binding energy was shifted to the higher binding energy. Furthermore, It is considered thatCu1.5Mn1.5O4 is superior to Mn oxides and CuO in the role as active factor of catalysts from the XRD results and alsocatalytic activities are dependent on the redox ability and high oxidation state of catalysts.