We report the synthesis, characterization, and determination of monomer reactivity ratios for the solution copolymerization of N,N-dimethylacrylamide (DMA) and 2-vinyl-4,4'-dimethylazlactone (VDMA). The polymerization kinetics were monitored by gas chromatography (GC), structure analysis of the resulting copolymers was determined using H-1-NMR analysis, and copolymer molecular weights were determined using gel-permeation chromatography (GPC). The reactivity ratios indicate the copolymerization of DMA and VDMA may result in greater mole fraction of VDMA in the copolymer compared to monomer feed compositions, especially when the DMA mole fraction is greater than the VDMA mole fraction. However, the data also indicates an azeotropic copolymerization at a mole fraction of VDMA of 0.78.