화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Polymer(Korea), Vol.30, No.1, 1-9, January, 2006
Export Citation
생체의료용 기능성 고분자 재료의 개발
Functional Polymeric Materials for Biomedical Application
성용길†, 송대경1, 성정석2
  • 동국대학교 화학과
  • 1신성대학 신소재학과
  • 2동국대학교 생명과학과
Yong Kiel Sung†, Dae Kyung Song1, and Jung Suk Sung2
  • Department of Chemistry, Dongguk University, Seoul 100-715, Korea
  • 1Department of Advanced Materials, Shinsung College, Chungnam 343-861, Korea
  • 2Department of Life Science, Dongguk University, Seoul 100-715, Korea
E-mail:
초록
생체의료용 기능성 고분자재료의 개발에 관한 연구를 고분자의 기능성, 생체적합성 및 생분해성을 토대로 다루었다. 본 연구실에서 합성한 기능성 생분해 고분자들을 비롯하여 생분해성 고분자 생체재료, 온도 감응성 고분자재료, 양이온성 고분자재료, 비축합성 고분자 생체재료, 조직공학을 위한 생체고분자 DNA 매트릭스 및 RNAi 기법을 위한 고분자 등의 기능성 고분자 생체재료에 관련된 연구들을 정리하고, 가까운 장래에 의료용으로 이용될 수 있는 기능성 생체고분자에 대한 연구들을 제안하였다.
The development of functional polymeric materials for biomedical application has progressed on the basis of functionality, biocompatibility and biodegradability. In this paper we review the functional polymeric biomaterials-based systems and propose a range of biomedical applications in the near future. These systems include the functional biodegradable polymers synthesized in our research laboratory, biodegradable polymeric materials, thermo-sensitive polymeric materials, cationic polymeric materials, non-condensing polymeric biomaterials, bio-polymeric DNA matrix for tissue engineering, and polymeric biomaterials for RNA interference (RNAi) technology.
Keywords:Functional polymers;polymeric biomaterials;biocompatibility;biodegradability;DNA;RNAi;gene carriers drug delivery systems;biomedical application
  1. Sung YK, Macromol. Chem. Symp., in "International Symposium on Synthesis and Characterization of Functional Polymeric Materials", C. H. Do and K. H. Yu, Editors, Korean Chemical Society, Seoul, Korea, Vol 14, p. 41 (2001)
  2. Sung YK, Kim SW, Korea Polym. J., 8(5), 199 (2000)
  3. Han S, Mahato RI, Sung YK, Kim SW, Mol. Ther., 2, 5713 (2000)
  4. Ledley FD, Pharm. Res., 13, 1595 (1996) 
  5. Mahato RI, Smith LC, Rolland A, Adv. Genet., 41, 95 (1999)
  6. Mahato I, Takakura Y, Hashida M, Crit. Rev. Ther. Drug Carr. Syst., 14, 133 (1997)
  7. Rolland A, Crit. Rev. Ther. Drug Carr. Syst., 15, 143 (1998)
  8. Tang MX, Szoka FC, Gene Ther., 4, 823 (1997) 
  9. Liu F, Qi H, Huang L, Liu D, Gene Ther., 4, 517 (1997) 
  10. Barry ME, Pinto-Gonzales D, Orson FM, Mckenzie GL, Petry GR, Barry MA, Hum. Gene Ther., 10, 2461 (1999) 
  11. De Smedt SC, Demeester J, Hennink WE, Pharm. Res., 17, 113 (2000) 
  12. Jeong B, Bae YH, Lee DS, Kim SW, Nature, 388(6645), 860 (1997) 
  13. Domb AJ, Kost J, Wiseman DM, Hand book of Biodegradable Polymer, Harwood Academic Publishers, The Netherlands (1997)
  14. Chain M, Langer R, (eds.), Biodegradable Polymers as Drug Delivery Systems, Marcel Dekker Inc., New York (1990)
  15. Shum-Tim D, Stock U, Hrkach J, Shinoka T, Lien J, Moses MA, Stamp A, Taylor G, Moran AM, Landis W, Langer R, Vacanti JP, Mayer JE, Ann. Thorac. Surg., 68, 2298 (1999) 
  16. Nishida H, Tokiwa Y, J. Appl. Polym. Sci., 46, 1467 (1992) 
  17. Okada M, Ito S, Aoi K, Atsumi M, J. Appl. Polym. Sci., 51(6), 1045 (1994) 
  18. Song DK, Lee JS, Sung YK, Polym.(Korea), 17(6), 710 (1993)
  19. Song DK, Sung YK, J. Appl. Polym. Sci., 56(11), 1381 (1995) 
  20. Sung YK, Oh MS, Song DK, Kim SW, Biomaterials and Drug Delivery toward New Millenium, K. D. Park, I. C. Kwon, N. Yui, S. Y. Jeong, and K. Park, Editors, Hanlymwon, Seoul, pp 669-685 (2000)
  21. Sung YK, Han SJ, Polym.(Korea), 25(1), 108 (2001)
  22. Sung YK, Song DK, Macromol. Symp., 118, 599 (1997)
  23. Sung YK, Song DK, Macromol. Symp., 224, 239 (2005) 
  24. Sung YK, Song DK, Oh MS, Biomaterials Res., 1, 20 (1997)
  25. Sung YK, Park CH, Song DK, Jung JH, J. KOSMBE, 13, 147 (1992)
  26. Kang IK, Kwon DR, Sung YK, Polym.(Korea), 15(4), 481 (1991)
  27. Kim H, Sung YK, Jung J, Baik H, Min TJ, Kim YS, J. Kor. Chem. Soc., 34, 203 (1990)
  28. Sung YK, Han SJ, Korea Polym. J., 7(1), 1 (1999)
  29. Lim YB, Han SO, Kong HU, Lee Y, Park JS, Jeong B, Kim SW, Pharm. Res., 17, 811 (2000) 
  30. Koh JJ, Ko KS, Lee M, Han SO, Park JS, Kim SW, Gene Ther., 12, 86 (2000)
  31. Maheshwari A, Mahato RI, McGregor J, Han SO, Samlowski WE, Park JS, Kim SW, Mol. Ther., 2, 121 (2000) 
  32. Lim YB, Choi YH, Park JS, J. Am. Chem. Soc., 121(24), 5633 (1999) 
  33. Putnam D, Langer R, Macromolecules, 32(11), 3658 (1999) 
  34. Wang D, Robinson DR, Kwon GS, Samuel J, J. Control. Release, 57, 9 (1999) 
  35. Hsu Y, Hao T, Hedley ML, J. Drug Target., 7, 313 (1999)
  36. Capan Y, Woo BH, Gebrekidan S, Ahmed S, DeLuca PP, Pharm. Res., 16, 509 (1999) 
  37. Maruyama A, Ishihara T, Kim JS, Kim SW, Akaike T, Bioconjugate Chem., 8, 735 (1997) 
  38. Heskins M, Guillet JE, J. Macromol. Sci. Chem., A2, 1441 (1968)
  39. Hinrichs WLJ, Schuurmans-Nieuwenbroek NME, van de Wetering P, Hennink WE, J. Control. Release, 60, 249 (1999) 
  40. Gao YL, Lach E, Kim TH, Rodriguez A, Arevalo CA, Vacanti CA, Plast. Reconstr. Surg., 102, 2293 (1998)
  41. Lemieux P, Guerin N, Paradis G, Proulx R, Christyakava L, Kabanov A, Alakhov V, Gene Ther., 7, 986 (2000) 
  42. Bochot A, Fattal E, Gulik A, Couarraze G, Couvreur P, Pharm. Res., 15, 1364 (1998) 
  43. Jeong B, Bae YH, Kim SW, J. Control. Release, 63, 155 (2000) 
  44. Yoo MK, Sung YK, Lee YM, Cho CS, Polymer, 41(15), 5713 (2000) 
  45. Sung YK, Yoo MK, Cho CS, Korea Polym. J., 8(1), 26 (2000)
  46. Yoo MK, Sung YK, Lee YM, Cho CS, Polymer, 39(16), 3703 (1998) 
  47. Yoo MK, Sung YK, Cho CS, Lee YM, Polymer, 38(11), 2759 (1997) 
  48. Yoo MK, Sung YK, J. Nat. Sci. RINS, 5, 63 (2000)
  49. Han SJ, Yoo MK, Sung YK, Lee YM, Cho CS, Macromol. Rapid Commun., 19, 403 (1998)
  50. Sung YK, Yoo MK, J. Nat. Sci. RINS, 1, 179 (1996)
  51. Yoo MK, Sung YK, J. Nat. Sci. Res. Inst., 15, 77 (1995)
  52. Byun J, Lee YM, Cho CS, Sun YK, Korea Polym. J., 3(1), 1 (1995)
  53. Jung JH, Sung YK, Korea Polym. J., 2(2), 85 (1994)
  54. Lee YM, Ihm SY, Shim JK, Cho CS, Sung YK, Materials in Clinical Applications, P. Vincenzini, Editor, Techna Srl, pp 213-220 (1995)
  55. Trubetskoy VS, Loomis A, Hagstrom JE, Budker VG, Wolff JA, Nucleic Acids Res., 27, 3090 (1999) 
  56. Gonsho A, Irie K, Susaki H, Iwasawa H, Okuno S, Sugawara T, Biol. Pharm., 17, 275 (1994)
  57. Maruyama A, Watanabe H, Ferdous A, Katoh M, Ishihara T, Akaike T, Bioconjugate Chem., 9, 292 (1998) 
  58. Ferdous A, Watanabe H, Akaike T, Maruyama A, J. Pharm. Sci., 87, 1400 (1998) 
  59. Boussif O, Delair T, Brua C, Veron L, Pavirani A, Kolbe HV, Bioconjugate Chem., 10, 877 (1999) 
  60. Choi YH, Liu F, Kim JS, Choi YK, Park JS, Kim SW, J. Control. Release, 54, 39 (1998) 
  61. MacLaughlin FC, Mumper RJ, Wang J, Tagliaferri JM, Gill I, Hinchcliffe M, Rolland AP, J. Control. Release, 56, 259 (1998) 
  62. Lee M, Nah JW, Kwon Y, Koh JJ, Ko KS, Kim SW, Pharm. Res., 18, 427 (2001) 
  63. Lee KY, Kwon IC, Kim YH, Jo WH, Jeong SY, J. Control. Release, 51, 213 (1998) 
  64. Erbacher P, Zou S, Bettinger T, Steffan AM, Remy JS, Pharm. Res., 15, 1332 (1998) 
  65. Roy K, Mao HQ, Huang SK, Leong KW, Nat. Med., 5, 387 (1999) 
  66. Lee YM, Kim SS, Park MH, Song KW, Sung YK, Kang IK, J. Mater. Sci. -Mater. Med., 11, 817 (2000) 
  67. Sung YK, Jeng KT, Polym.(Korea), 21(6), 921 (1997)
  68. Sung YK, Kim SJ, Lee YM, Kang IK, J. Kor. Soc. Med. Biol. Eng., 16, 257 (1995)
  69. Kim KY, Lee SY, Min DS, Cho YJ, Chung YH, Kim JM, Park JH, Sung YK, Cho CS, Polym.(Korea), 14(4), 427 (1990)
  70. Boussif O, Lezoualc'h F, Zanta MA, Mergny MD, Scherman D, Demeniex B, Behr JP, Proc. Natl. Acad. Sci. USA, 92, 7297 (1995) 
  71. Coll JL, Chollet P, Brambilla E, Desplanques D, Behr JP, Favort M, Hum. Gene Ther., 10, 1659 (1999) 
  72. Garnett MC, Crit. Rev. Ther. Drug Carr. Syst., 16, 147 (1999)
  73. Behr JP, Demeneix BA, Curr. Res. Mol. Ther., 1, 5 (1998)
  74. Lemkine GF, Goula D, Becker N, Paura L, Levi G, Demeneix BA, J. Drug Target., 7, 305 (1999)
  75. Ogris M, Brunner S, Schuller S, Kircheis R, Wagner E, Gene Ther., 6, 595 (2000) 
  76. Nguyen HK, Lemieux P, Vinogradov SV, Gebhart CL, Guerin N, Paradis G, Bronich TK, Alakhov VY, Kabanov AV, Gene Ther., 7, 126 (2000) 
  77. Sung YK, Kim YJ, Grainger DW, Okano T, Kim SW, Korea Polym. J., 1(1), 14 (1993)
  78. Cho CS, Kim HY, Sung YK, Korea Polym. J., 1(1), 57 (1993)
  79. Grainger DW, Okano T, Kim SW, Castner DG, Ratner BD, Briggs D, Sung YK, J. Biomed. Mater. Res., 24, 547 (1990) 
  80. Sung YK, Kim YH, Jung JH, J. Nat. Sci, 32, 43 (1993)
  81. Zuidam NJ, Posthurma G, de Vries ET, Crommelin DJ, Hennink WE, Storm G, J. Drug Target., 8, 51 (2000)
  82. Arigita C, Zuidam NJ, Crommelin DJ, Hennink WE, Pharm. Res., 16, 1534 (1999) 
  83. Cherng JY, van de Watering P, Talsma H, Crommelin DJ, Hennink WE, Pharm. Res., 13, 1038 (1996) 
  84. Cherng JY, Talsma H, Crommelin DJ, Hennink WE, Pharm. Res., 16, 1417 (1999) 
  85. Park JS, Lim YB, Kwon YM, Jeong B, Choi YH, Kim SW, J. Polym. Sci. A: Polym. Chem., 37(14), 2305 (1999) 
  86. Haensler J, Szoka FC, Bioconjugate Chem., 4, 372 (1998)
  87. Tang MX, Redemann CT, Szoka FC, Bioconjugate Chem., 7, 703 (1996) 
  88. Kukowska-Latallo JF, Bielinska AU, Johnson J, Spindler R, Tomalia DA, Baker JB, Proc. Natl. Acad. Sci. USA, 93, 4897 (1996) 
  89. Maruyama-Tabata H, Harada Y, Matsumura T, Satoh E, Cui F, Iwai M, Kita M, Hibi S, Imanishi J, Sawada T, Mazda O, Gene Ther., 7, 53 (2000) 
  90. Mumper RJ, Wang J, Klakamp SL, Nitta H, Anwer K, Tagliaferri F, Rolland AP, J. Control. Release, 52, 191 (1998) 
  91. Sung YK, Gregonis DE, Jhon MS, Andrade JD, J. Appl. Polym. Sci., 26, 3719 (1981) 
  92. Sung YK, Gregonis DE, Russell GA, Andrade JD, Polymer, 19, 1362 (1978) 
  93. Sung YK, Jhon MS, Gregonis DE, Andrade JD, Polym.(Korea), 8(2), 123 (1984)
  94. Sung YK, Jhon MS, Gregonis DE, Andrade JD, Polym.(Korea), 8(2), 123 (1984)
  95. Mumper RJ, Duguid JG, Anwer K, Barron MK, Nitta H, Rolland P, Pharm. Res., 13, 701 (1996) 
  96. Mumper RJ, Wang J, Klakamp SL, Nitta H, Anwer K, Tagliaferri F, Rolland AP, J. Control. Release, 52, 191 (1998) 
  97. Bronich TK, Nguyen HK, Eisenberg A, Kabanov A, Polymer Preprints, 41, 1006 (2000)
  98. Astafieva I, Maksimova I, Lukanidin E, Alakhov V, Kabanov A, Febs Lett., 389, 278 (1996) 
  99. cho CS, Jeong YI, Kim SH, Nah JW, Lee YM, Kang IK, Sung YK, Korea Polym. J., 7(3), 203 (1999)
  100. Shin IG, Kim SY, Lee YM, Cho CS, Sung YK, J. Control. Release, 51, 1 (1998) 
  101. Kim SY, Shin IG, Lee YM, Cho CS, Sung YK, J. Control. Release, 51, 13 (1998) 
  102. Jeong YI, Cheon JB, Kim SH, Nah JW, Lee YM, Sung YK, Akaike T, Cho CS, J. Control. Release, 51, 169 (1998) 
  103. Shea D, Smiley E, Bonadio J, Mooney DJ, Nat. Biotechnol., 17, 551 (1999) 
  104. Bonadio J, Smiley E, Patil P, Goldstein S, Nat. Med., 5, 753 (1999) 
  105. Ochiya T, Takahama Y, Nagahara S, Sumita Y, Nat. Med., 5, 707 (1999) 
  106. Remes A, Williams DF, Biomaterials, 5, 707 (1992)
  107. Urban-Klein B, Werth S, Abuharbeid S, Czubayko F, Aigner A, Gene Ther., 12, 461 (2005) 
  108. Kim SH, Jeong JH, Cho KC, Kim SW, Park TG, J. Control. Release, 104, 223 (2005) 
  109. Schiffelers RM, Ansari A, Xu J, Zhou Q, Tang Q, Storm G, Molema G, Lu PY, Scaria PV, Woodle MC, Nucleic Acids Res., 32, 149 (2004) 
  110. Kakizawa Y, Furukawa S, Kataoka K, J. Control. Release, 97, 345 (2004)