CuO/Ce0.8Zr0.2O2 and CuO/CeO2 catalysts were prepared via a impregnation method characterized by using FT-Raman, XRD, XPS and H-2-TPR technologies. The catalytic activity of the samples for low-temperature CO oxidation was investigated by means of a microreactor-GC system. The influence of the calcination temperature and different supports on the catalytic activity was studied.