The conductance of interpenetrated polymer networks (IPNs) containing quaternary amino groups was studied in cyclohexane, toluene, ethyl ether, ethyl acetate, and tetrahydrofurane as a function of water content by electrochemical impedance spectroscopy. IPNs were then used as sensitive materials to detect water traces in organic solvents with promising results for the construction of a moisture sensor. The detection onset for water concentration increased with the dielectric constant of the solvent. Different IPN-based sensors in the same solvent showed a detection limit at lower water concentration if their characteristic plot [conductance/relative humidity (RH%) in air] was shifted toward lower RH%. This suggests that the composition of this class of polymers can be tuned to achieve the best performance for each solvent.