Dehydrogenation of propane in the presence and absence of CO2 over CrOx/SiO2 and CrOx/Al2O3 catalysts with Cr loading between 0.7-20.4 wt% was discussed. It was found that the nature of support strongly effects on the catalytic performance in the dehydrogenation with CO2. Over the CrOx/SiO2 catalyst CO2 enhance the propene yield, whereas over the CrOx/Al2O3 catalyst the yield and selectivity of propene in the presence of CO2 strongly decrease. The effect of steam on catalytic performance of the tested catalysts was also discussed.